Invitrogen™ TMED2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120563

Catalog No. PIPA5120563

Description

Positive test controls include: U-87MG, HepG2, Mouse liver, Mouse kidney, Rat spleen, Rat lung, Rat liver. Immunogen sequence: EITGPDNKGI YKGDRESSGK YTFAAHMDGT YKFCFSNRMS TMTPKIVMFT IDIGEAPKGQ DMETEAHQNK LEEMINELAV AMTAVKHEQE YMEVRERIHR AINDNTNSRV V.

TMED2 is a protein coding gene involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.

Specifications

• Antigen: TMED2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tmed2
• Gene Alias: 1110032D12Rik; 1810020N21Rik; coated vesicle membrane protein; COPI-coated vesicle membrane protein p24; Membrane protein p24A; p24; p24 family protein beta-1; P24A; p24b1; p24beta1; RNP21.4; RNP24; sid 394; Sid394; Sid394p; TMED2; transmembrane emp24 domain trafficking protein 2; transmembrane emp24 domain-containing protein 2; transmembrane p24 trafficking protein 2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10959, 56334, 65165
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 2.56 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q15363, Q63524, Q9R0Q3
• Gene Symbols: Tmed2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 60-170 of human TMED2 (NP_006806.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG