Invitrogen™ TMEFF1 Polyclonal Antibody

Catalog No.	Quantity
PIPA547998	100 μg

Catalog No. PIPA547998 Supplier Invitrogen™ Supplier No. PA547998

Description

Goat Polyclonal Antibody

In direct ELISAs and Western blots, approximately 40% cross-reactivity with recombinant human (rh) TMEFF1 is observed and less than 5% cross-reactivity with rhTMEFF2 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

The TMEFF1 gene encodes the protein transmembrane protein with ependymin domain 1, which is involved in cellular signaling and neural development. TMEFF1, characterized by its transmembrane and ependymin-related domains, plays a role in the modulation of cell-cell interactions and signaling pathways essential for brain development and function. This protein is expressed predominantly in the central nervous system, where it influences neuronal differentiation and synaptic formation, contributing to the establishment and maintenance of neural circuits. TMEFF1 has been implicated in neuroprotective functions, where it supports neuronal survival in response to stress or injury. Additionally, its expression has been studied in the context of cancer biology, particularly in brain tumors, where TMEFF1 might impact tumor growth and progression through its effects on cell signaling and adhesion. Research continues to explore the specific mechanisms and interactions of TMEFF1 to better understand its roles in neural health and disease, particularly in neurodevelopmental disorders and cancer.

Specifications

• Antigen: TMEFF1
• Applications: Immunohistochemistry (Frozen), Western Blot
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5% trehalose and No Preservative
• Gene: TMEFF1
• Gene Accession No.: Q6PFE7
• Gene Alias: A830033E11; C9orf2; cancer/testis antigen family 120, member 1; CT120.1; H7365; H7365member 1; M7365; Nc1; Protein NC1; TMEFF1; Tomoregulin-1; Tr1; TR-1; transmembrane protein with EGF like and two follistatin like domains 1; transmembrane protein with EGF-like and one follistatin-like domain; transmembrane protein with EGF-like and two follistatin-like domains 1
• Gene Symbols: TMEFF1
• Host Species: Goat
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse TMEFF1/Tomoregulin-1 Ser37-Thr320.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 230157
• Target Species: Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG