Invitrogen™ TMEM100 Monoclonal Antibody (OTI1F8)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524941

Catalog No. PIMA524941

Description

TMEM100 Monoclonal Antibody for Western Blot, IHC (P)

Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. [UniProt].

Specifications

• Antigen: TMEM100
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9NV29
• Gene Symbols: TMEM100
• Immunogen: Full-length protein expressed in 293T cell transfected with human TMEM100 expression vector.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Canine, Monkey
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1F8
• Conjugate: Unconjugated
• Gene: TMEM100
• Gene Alias: EGK_08550; TMEM100; Transmembrane protein 100
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55273, 609661
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid