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Invitrogen™ TMEM108 Polyclonal Antibody
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Catalog No. PIPA585485
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100 μL
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PIPA585485 100 μL
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Catalog No. PIPA585485 Supplier Invitrogen™ Supplier No. PA585485
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Description

Rabbit Polyclonal Antibody

Keep as concentrated solution. Predicted reactivity: Rhesus Monkey (92%). Positive Control: SH-SY5Y. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Transmembrane protein 108 (TMEM108) is a gene associated with psychiatric disorders such as schizophrenia, bipolar disorder, and major depression disorder. It is specifically expressed in the nervous system, particularly enriched in the postsynaptic density fraction and DG granule neurons. Research has shown that TMEM108 is critical for adult neurogenesis in the hippocampal dentate gyrus, indicating its role in neuronal development and function. Studies with TMEM108 mutant mice exhibit mania-like behavior, highlighting its involvement in the pathology of bipolar disorder. The gene's expression is notably higher in oligodendrocyte lineage cells within the central nervous system compared to other lineage cells. As a schizophrenia susceptibility gene, TMEM108 has been identified as a potential target for understanding the underlying mechanisms of psychiatric diseases and for developing therapeutic approaches. However, the detailed pathophysiological mechanisms by which TMEM108 contributes to such disorders remain largely unknown.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TMEM108
Applications Western Blot
Classification Polyclonal
Concentration 0.8 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene TMEM108
Gene Accession No. Q6UXF1
Gene Alias AI462967; B130017P16Rik; cancer/testis antigen 124; CT124; KIAA1690; R74726; retrolinkin; RGD1311530; RTLN; TMEM108; Transmembrane protein 108; UNQ1875/PRO4318
Gene Symbols TMEM108
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human TMEM108. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 66000
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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