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Invitrogen™ TMEM119 Polyclonal Antibody
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Catalog No. PIPA5120705
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100 μL
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PIPA5120705 100 μL
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Catalog No. PIPA5120705 Supplier Invitrogen™ Supplier No. PA5120705
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Description

Rabbit Polyclonal Antibody

Positive test controls include: Mouse liver, Mouse brain, Rat brain. Immunogen sequence: SRPEEALDSS RQLQADILAA TQNLKSPTRA ALGGGDGARM VEGRGAEEEE KGSQEGDQEV QGHGVPVETP EAQEEPCSGV LEGAVVAGEG QGELEGSLLL AQEAQGPVGP P.

Tmem119 encodes a single-pass type I transmembrane protein which seems to interact with a multitude of micro-RNAs as well as certain transcription factors such as SMAD1, SMAD5 and RUNX2. Tmem119 has been identified as a surface marker of microglia that can be used to reliably distinguish microglia from infiltrating macrophages. Microglial cells are phagocytes that are restricted to the brain and involved in clearing up debris and dendrite pruning of neurons. They display a high functional plasticity, balancing neuroprotective and neurotoxic functions, which is reflected by their distinct physiology in response to changes in their microenvironment. Microglia are particularly mobile in areas of the brain undergoing restructuring. Reactive microglia co-express the marker Iba1. In a pathological context, microglia have been associated with differentiation of pathogenic/inflammatory A1 type astrocytes by secretion of Cq1, IL-1a and TNF when stimulated with LPS, and thought to contribute to the pathology of several neurodegenerative diseases such as Alzheimers, Parkinsons, Chorea Huntingtons disease and Multiple Sclerosis. The specific function Tmem119 plays on microglial cells remains unclear. Outside of the neural system, Tmem119 seems to be involved in osteoblast differentiation/ossification.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TMEM119
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 2.11 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene TMEM119
Gene Accession No. Q8R138
Gene Alias AW208946; BC025600; OBIF; Osteoblast induction factor; PSEC0199; Tmem119; Transmembrane protein 119; UNQ731/PRO1415
Gene Symbols TMEM119
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 231633, 304581
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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