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Invitrogen™ TMEM18 Polyclonal Antibody
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Catalog No. PIPA559113
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100 μL
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PIPA559113 100 μL
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Catalog No. PIPA559113 Supplier Invitrogen™ Supplier No. PA559113
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MPSAFSVSSF PVSIPAVLTQ TDWTEP Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 69%.

Recent studies have examined how overexpression of certain genes enhances the tropism of neural stem cells (NSCs) for gliomas. Overexpression of Transmembrane protein 18 (TMEM18) provides NSCs and neural precursors an increased migration capacity towards glioblastoma cells in vitro and in the rat brain, while functional inactivation of the gene resulted in an almost complete loss of migration activity, suggesting that TMEM18 could be a potential target in NSC-based glioma therapy. Other recent results suggest that among others, the TMEM18 loci is associated with higher than normal body mass index (BMI) and obesity, indicating there may be a CNS-related role in predisposition to obesity. Multiple isoforms of TMEM18 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TMEM18
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TMEM18
Gene Accession No. Q96B42
Gene Alias BC024093; TMEM18; Transmembrane protein 18
Gene Symbols TMEM18
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TMEM18. Recombinant protein control fragment (Product #RP-91083).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 129787
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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