Invitrogen™ TMEM18 Polyclonal Antibody

Catalog No.	Quantity
PIPA5116855	100 μL

Catalog No. PIPA5116855 Supplier Invitrogen™ Supplier No. PA5116855

Description

Rabbit Polyclonal Antibody

Positive Samples: HeLa, A-549, Rat kidney Immunogen sequence: LLTCLSSRSY RLQIGHFLCL VILVYCAEYI NEAAAMNWRL FSKYQYFDSR GMFISIVFSA P.

Recent studies have examined how overexpression of certain genes enhances the tropism of neural stem cells (NSCs) for gliomas. Overexpression of Transmembrane protein 18 (TMEM18) provides NSCs and neural precursors an increased migration capacity towards glioblastoma cells in vitro and in the rat brain, while functional inactivation of the gene resulted in an almost complete loss of migration activity, suggesting that TMEM18 could be a potential target in NSC-based glioma therapy. Other recent results suggest that among others, the TMEM18 loci is associated with higher than normal body mass index (BMI) and obesity, indicating there may be a CNS-related role in predisposition to obesity. Multiple isoforms of TMEM18 are known to exist.

Specifications

• Antigen: TMEM18
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 1.33 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: TMEM18
• Gene Accession No.: Q6DGF8, Q96B42
• Gene Alias: BC024093; TMEM18; Transmembrane protein 18
• Gene Symbols: TMEM18
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 40-100 of human TMEM18 (NP_6900472).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 129787, 362722
• Target Species: Human, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG