Invitrogen™ TMEM184C Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA562896

Catalog No. PIPA562896

Description

Immunogen sequence: LSSSSQDAIS IASSMPPSPM GHYQGFGHTV TPQTTPTTAK ISDEILSDTI GEKKEPSDKS VD Highest antigen sequence identity to the following orthologs: Mouse - 45%, Rat - 40%.

Anaplastic thyroid cancer is one of the most lethal forms of cancer, but the precise carcinogenic mechanism has not been identified. TMEM184C, also known as TMEM34, was identified in a cDNA microarray analysis as being down-regulated in anaplastic thyroid cancers compared to normal thyroid tissues. TMEM184C protein expression was also lower in cell lines derived from these types of cancers compared to that of normal thyroid tissues or cell lines based on other types of thyroid cancers. Furthermore, transfection of TMEM34 into KTA2 cells led to the inhibition of cell growth, suggesting that TMEM184C might act as a tumor suppressor in anaplastic thyroid cancers.

Specifications

• Antigen: TMEM184C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TMEM184C
• Gene Alias: 8430433H16Rik; AI645453; AL033298; BC004056; DNA sequence AY228474; PRO1355; TMEM184C; Tmem34; Transmembrane protein 184C; transmembrane protein 34
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55751
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NVA4
• Gene Symbols: TMEM184C
• Immunogen: Recombinant protein corresponding to Human TMEM184C. Recombinant protein control fragment (Product #RP-101430).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG