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Invitrogen™ TMEM2 Polyclonal Antibody
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Catalog No. PIPA5106963
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100 μL
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PIPA5106963 100 μL
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Catalog No. PIPA5106963 Supplier Invitrogen™ Supplier No. PA5106963
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Description

Rabbit Polyclonal Antibody

Sequence homology: Cow: 86%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 100% Immunogen sequence: MLTGLCQGCG TRQVVFTSDP HKSYLPVQFQ SPDKAETQRG DPSVISVNGT.

This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TMEM2
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
Gene CEMIP2
Gene Accession No. Q9UHN6
Gene Alias basic helix-loop-helix domain containing, class B, 2; BHLHB2; cell migration inducing hyaluronidase 2; Cell migration-inducing hyaluronidase 2; Cell surface hyaluronidase; CEMIP2; Kiaa1412; Tmem2; transmembrane protein 2
Gene Symbols CEMIP2
Host Species Rabbit
Immunogen Synthetic peptide directed towards the middle region of human TMEM2 (aa 1187-1237).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23670
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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