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Invitrogen™ TMEM24 Polyclonal Antibody
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Catalog No. PIPA5107087
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PIPA5107087 100 μL
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Catalog No. PIPA5107087 Supplier Invitrogen™ Supplier No. PA5107087
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Description

Rabbit Polyclonal Antibody

Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%.

Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen TMEM24
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
Gene C2CD2L
Gene Accession No. O14523
Gene Alias 1300006O23Rik; C2 calcium-dependent domain containing 2-like; C2 domain-containing protein 2-like; C2 domain-containing protein 2-like; phospholipid transfer protein C2CD2L; c2cd2 like; C2cd2l; C2CD2-like; DLNB23; KIAA0285; Phospholipid transfer protein C2CD2L; tmem24; Transmembrane protein 24; zgc:153961
Gene Symbols C2CD2L
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C-terminal region of human TMEM24 (aa 657-706).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9854
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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