Invitrogen™ TMEM38A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA562194

Catalog No. PIPA562194

Description

Immunogen sequence: THSHSSPFDA LEGYICPVLF GSACGGDHHH DNHGGSHSGG GPGAQHSAMP AKSKEELSEG SRKK Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 78%.

TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.

Specifications

• Antigen: TMEM38A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tmem38a
• Gene Alias: 1110001E17Rik; 27 kDa sarcoplasmic reticulum protein; AI413399; mg33a; Mitsugumin33A; Mitsugumin-33A; RGD1307901; sarcoplasmic reticulum protein 27; SPR-27; Srp-27; TMEM38A; tmem38a {ECO:0000250; Transmembrane protein 38A; TRICA; TRIC-A; trimeric intracellular cation channel type A; UniProtKB:Q3TMP8}
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79041
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9H6F2
• Gene Symbols: Tmem38a
• Immunogen: Recombinant protein corresponding to Human TMEM38A. Recombinant protein control fragment (Product #RP-100827).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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