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Invitrogen™ TMEM38A Polyclonal Antibody
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Catalog No. PIPA562194
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PIPA562194 100 μL
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Catalog No. PIPA562194 Supplier Invitrogen™ Supplier No. PA562194
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: THSHSSPFDA LEGYICPVLF GSACGGDHHH DNHGGSHSGG GPGAQHSAMP AKSKEELSEG SRKK Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 78%.

TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TMEM38A
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Tmem38a
Gene Accession No. Q9H6F2
Gene Alias 1110001E17Rik; 27 kDa sarcoplasmic reticulum protein; AI413399; mg33a; Mitsugumin33A; Mitsugumin-33A; RGD1307901; sarcoplasmic reticulum protein 27; SPR-27; Srp-27; TMEM38A; tmem38a {ECO:0000250; Transmembrane protein 38A; TRICA; TRIC-A; trimeric intracellular cation channel type A; UniProtKB:Q3TMP8}
Gene Symbols Tmem38a
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TMEM38A. Recombinant protein control fragment (Product #RP-100827).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79041
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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