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Invitrogen™ TMEM38B Polyclonal Antibody
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Catalog No. PIPA553809
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100 μL
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PIPA553809 100 μL
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Catalog No. PIPA553809 Supplier Invitrogen™ Supplier No. PA553809
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FEDTLSWMLF GWQQPFSSCE KKSEAKSPSN GVGSLASKPV DVASDNV Highest antigen sequence identity to the following orthologs: Mouse - 53%, Rat - 52%.

TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TMEM38B
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TMEM38B
Gene Accession No. Q9NVV0
Gene Alias 1600017F22Rik; AA437809; AV051057; bA219P18.1; C9orf87; D4Ertd89e; mg33b; Mitsugumin33B; Mitsugumin-33B; OI14; RGD1305703; RP11-219P18.1; TMEM38B; Transmembrane protein 38B; TRICB; TRIC-B; trimeric intracellular cation channel type B
Gene Symbols TMEM38B
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TMEM38B. Recombinant protein control fragment (Product #RP-91197).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55151
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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