Invitrogen™ TMEM43 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA548409

Catalog No. PA548409

Description

Predicted to react with mouse and rat based on sequence homology.

This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC.

Specifications

• Antigen: TMEM43
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TMEM43
• Gene Alias: 1200015A22Rik; ARVC5; ARVD5; EDMD7; LUMA; Protein LUMA; Tmem43; Transmembrane protein 43; UNQ2564/PRO6244
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 79188
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q9BTV4
• Gene Symbols: TMEM43
• Immunogen: KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human TMEM43.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG