Invitrogen™ TMEM52B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563525

Catalog No. PIPA563525

Description

Immunogen sequence: QLPSSLDTLP GYEEALHMSR FTVAMCGQKA PDLPPVPEEK QLPPTEKEST RIVDSWN Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 77%.

The TMEM52B gene encodes a transmembrane protein that is widely expressed across various normal human tissues, suggesting its fundamental role in maintaining cellular integrity. TMEM52B is part of the transmembrane protein (TMEM) family, which contains proteins that span biological membranes, including the lipid bilayer of the plasma membrane and organelle membranes. This gene is notably involved in tumor biology, where it modulates cancer cell survival and invasion. Studies have shown that suppression of TMEM52B expression can enhance the aggressiveness of cancer cells, indicating its potential as a tumor suppressor gene. Specifically, TMEM52B isoforms such as P18 and P20 have been found to differentially influence tumor dynamics, particularly in the context of nasopharyngeal carcinoma (NPC). While its exact molecular mechanisms remain largely unknown, the regulation of TMEM52B is crucial for controlling tumor growth and metastasis. Therefore, understanding its role could provide insights into therapeutic strategies aimed at curbing cancer progression.

Specifications

• Antigen: TMEM52B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TMEM52B
• Gene Alias: C12orf59; TMEM52B; Transmembrane protein 52B; UNQ5927/PRO19821
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 120939
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q4KMG9
• Gene Symbols: TMEM52B
• Immunogen: Recombinant protein corresponding to Human TMEM52B. Recombinant protein control fragment (Product #RP-104253).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG