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Invitrogen™ TMEM59 Polyclonal Antibody
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Catalog No. PIPA5140175
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100 μL
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PIPA5140175 100 μL
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Catalog No. PIPA5140175 Supplier Invitrogen™ Supplier No. PA5140175
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Description

Rabbit Polyclonal Antibody

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: HLLFPLTLVR SFWSDMMDSA QSFITSSWTF YLQADDGKIV IFQSKPEIQY APHLEQEPTN LRESSLSKMS SDLQMRNSQA HRNFLEDGES DGFLRCLSLN SGW Highest antigen sequence indentity to the following orthologs: Mouse - 94%, Rat - 92%.

Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TMEM59
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TMEM59
Gene Accession No. Q9BXS4
Gene Alias 1110001M20Rik; 3110046P06Rik; AI256529; C1orf8; D4Ertd20e; DCF1; dendritic cell factor 1; HSPC001; Liver membrane-bound protein; MTDCF1; ORF18; PRO195; RGD1310313; RP4-758J24.2; Tdcf1; Thymic dendritic cell-derived factor 1; TMEM59; Transmembrane protein 59; UNQ169; UNQ169/PRO195
Gene Symbols TMEM59
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TMEM59. Recombinant protein control fragment (Product #RP-109480).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9528
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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