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Invitrogen™ TMEM8A Polyclonal Antibody
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Catalog No. PIPA566706
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PIPA566706 100 μL
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Catalog No. PIPA566706 Supplier Invitrogen™ Supplier No. PA566706
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PFLGFNTSLNC TTAFFQGYPL SLSAWSRRAN LIIPYPETDN WYLSLQLMCP ENAEDCEQAV VHVETTLYLV PC Highest antigen sequence identity to the following orthologs - mouse 81%, rat 82%.

Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen TMEM8A
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TMEM8A
Gene Accession No. Q9HCN3
Gene Alias five-span transmembrane protein M83; GPI processing phospholipase A2; GPI-PLA2; M83; PGAP6; Post-GPI attachment to proteins factor 6; Protein M83; TMEM6; TMEM8; TMEM8A; Transmembrane protein 6; Transmembrane protein 8; transmembrane protein 8 (five membrane-spanning domains); transmembrane protein 8A
Gene Symbols TMEM8A
Host Species Rabbit
Immunogen Recombinant Human TMEM8A. Recombinant protein control fragment (Product #RP-107355).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 58986
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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