TMEM8A Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA562365

Catalog No. PIPA562365

Description

Immunogen sequence: TCAYVFQPEL LVTRVVEISI MEPDVPLPQT LLSHPSYLKV FVPDYTRELL LELRDCVSNG SLGCPVRLTV GPVTLPSNFQ KVL Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 75%.

Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401). [UniProt]

Specifications

• Antigen: TMEM8A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TMEM8A
• Gene Alias: five-span transmembrane protein M83; GPI processing phospholipase A2; GPI-PLA2; M83; PGAP6; Post-GPI attachment to proteins factor 6; Protein M83; TMEM6; TMEM8; TMEM8A; Transmembrane protein 6; Transmembrane protein 8; transmembrane protein 8 (five membrane-spanning domains); transmembrane protein 8A
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 58986
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9HCN3
• Gene Symbols: TMEM8A
• Immunogen: Recombinant protein corresponding to Human TMEM8A
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov

Research Use Only