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Invitrogen™ TMPRSS11B Polyclonal Antibody
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Catalog No. PIPA531481
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100 μL
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Catalog No. Quantity
PIPA531481 100 μL
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Catalog No. PIPA531481 Supplier Invitrogen™ Supplier No. PA531481
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: A549, HeLa, HCT116. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

TMPRSS11B, a member of the transmembrane serine protease family, has recently gained attention for its role in promoting tumor growth, particularly in lung squamous cell carcinomas (LSCCs). This gene is located on chromosome 4q13.2 and encodes a protein involved in proteolytic processing of substrates, impacting cellular communication and tissue homeostasis. TMPRSS11B is upregulated in LSCCs, and its high expression correlates with poor survival rates in non-small cell lung cancer patients. Research has demonstrated that TMPRSS11B facilitates metabolic reprogramming in cancer cells, aiding their transformation and proliferation. In vitro studies with immortalized human bronchial epithelial cells have shown that TMPRSS11B enhances tumor growth, indicating its potential as a therapeutic target for lung cancer treatment. Moreover, TMPRSS11B depletion in immunocompetent mice led to reduced tumor burden and increased infiltration of immune cells, suggesting its influence on the tumor microenvironment.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TMPRSS11B
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene TMPRSS11B
Gene Accession No. Q86T26
Gene Alias airway trypsin-like protease 5; HATL5; TMPRSS11B; Transmembrane protease serine 11B; transmembrane protease, serine 11B
Gene Symbols TMPRSS11B
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the Extracellular domain of human TMPRSS11B. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 132724
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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