Invitrogen™ TMPRSS6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA543989

Catalog No. PIPA543989

Description

Peptide sequence: LLWYFLGYKA EVMVSQVYSG SLRVLNRHFS QDLTRRESSA FRSETAKAQK Sequence homology: Cow: 100%; Dog: 93%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%.

TMPRSS6 is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. TMPRSS6 can also activate urokinase-type plasminogen activator with low efficiency. TMPRSS6 may play a specialized role in matrix remodeling processes in liver. TMPRSS6 is required to sense iron deficiency. Overexpression of TMPRSS6 suppresses activation of the HAMP promoter. The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.

Specifications

• Antigen: TMPRSS6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TMPRSS6
• Gene Alias: 1300008A22Rik; IRIDA; matriptase 2; matriptase-2; membrane-bound mosaic serine proteinase matriptase-2; Tmprss6; Transmembrane protease serine 6; transmembrane protease, serine 6; transmembrane serine protease 6; type II transmembrane serine protease 6; UNQ354/PRO618
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 164656
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q8IU80
• Gene Symbols: TMPRSS6
• Immunogen: Synthetic peptide directed towards the N-terminal of human TMPRSS6 (aa 71-120).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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