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Invitrogen™ TMSB4X Polyclonal Antibody
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Catalog No. PA550584
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PA550584 100 μL
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Catalog No. PA550584 Supplier Invitrogen™ Supplier No. PA550584
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total Thymosin beta 4 protein.

Thymosin-beta4 is a small, actin-sequestering protein belonging to the thymosin-beta family that is found at high concentrations within the spleen, thymus, and peritoneal macrophages, where it is most notably responsible for the organization of cytoskeletal structure. In mammalian tissues, this protein acts as a modulator for the polymerization/depolymerization of actin through the formation of a 1:1 complex with the monomer G (globular)-actin, and inhibits actin's polymerization to form F (filamentous) actin, which together with other proteins binds microfilaments to construct the cytoskeleton. Commonly found at significant quantities within the brain, lungs, liver, kidneys, testes, and heart, thymosin-beta4 has also been shown to be synthesized by cells unrelated to the reticuloendothelial system, such as myoblasts and fibroblasts, and expressed at irregular levels by several hemopoietic cell lines, malignant lymphoid cells and myeloma cells. In addition to regulating actin polymerization, research has also found thymosin-beta4 to stimulate the secretion of hypothalamic luteinizing hormone-releasing hormone and luteinizing hormone, inhibit the migration of peritoneal macrophages, induce phenotypic changes in T cell lines during early host defense mechanisms, and inhibit the progression of hematopoietic pluripotent stem cells into the S-phase.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TMSB4X
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene TMSB4X
Gene Accession No. P20065, P62328, P62329
Gene Alias Fx; Hematopoietic system regulatory peptide; prothymosin beta 4; prothymosin beta-4; Ptmb4; Seraspenide; T beta 4; t beta-4; Tb4; TB4X; TB4Xbeta 4; Thyb4; thymosin; thymosin beta 4; thymosin beta 4, X-linked; thymosin beta-4; thymosin, beta 4, X chromosome; Tmsb4; Tmsb4x
Gene Symbols TMSB4X
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues near the N terminal of human thymosin beta 4, X-linked.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19241, 7114, 81814
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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