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Invitrogen™ TMSB4X Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA547875

Catalog No. PIPA547875


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Description

Description

In direct ELISAs, approximately 5% cross-reactivity with recombinant human (rh) Thymosin beta 10 and rhThymosin beta 16 is observed. Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

Thymosin-beta4 is a small, actin-sequestering protein belonging to the thymosin-beta family that is found at high concentrations within the spleen, thymus, and peritoneal macrophages, where it is most notably responsible for the organization of cytoskeletal structure. In mammalian tissues, this protein acts as a modulator for the polymerization/depolymerization of actin through the formation of a 1:1 complex with the monomer G (globular)-actin, and inhibits actin's polymerization to form F (filamentous) actin, which together with other proteins binds microfilaments to construct the cytoskeleton. Commonly found at significant quantities within the brain, lungs, liver, kidneys, testes, and heart, thymosin-beta4 has also been shown to be synthesized by cells unrelated to the reticuloendothelial system, such as myoblasts and fibroblasts, and expressed at irregular levels by several hemopoietic cell lines, malignant lymphoid cells and myeloma cells. In addition to regulating actin polymerization, research has also found thymosin-beta4 to stimulate the secretion of hypothalamic luteinizing hormone-releasing hormone and luteinizing hormone, inhibit the migration of peritoneal macrophages, induce phenotypic changes in T cell lines during early host defense mechanisms, and inhibit the progression of hematopoietic pluripotent stem cells into the S-phase.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

TMSB4X
Polyclonal
Unconjugated
TMSB4X
Fx; Hematopoietic system regulatory peptide; prothymosin beta 4; prothymosin beta-4; Ptmb4; Seraspenide; T beta 4; t beta-4; Tb4; TB4X; TB4Xbeta 4; Thyb4; thymosin; thymosin beta 4; thymosin beta 4, X-linked; thymosin beta-4; thymosin, beta 4, X chromosome; Tmsb4; Tmsb4x
Sheep
Antigen affinity chromatography
RUO
7114
-20°C, Avoid Freeze/Thaw Cycles
Lyophilized
Western Blot, Immunocytochemistry
0.2 mg/mL
PBS with 5% trehalose and No Preservative
P62328
TMSB4X
E. coli-derived recombinant human Thymosin beta 4 Ser2-Ser44.
100 μg
Primary
Human
Antibody
IgG
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