Invitrogen™ Tn Antigen Monoclonal Antibody (Tn 218)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA190544

Catalog No. MA190544

Description

MA1-90544 stains Tn antigen in epithelial carcinoma, pancreatic, colon, stomach and breast. A suggested positive control for this product is human gastrointestinal tumor. The antibody is supplied as concentrated tissue culture supernatant in PBS with 0.05% azide.

Aberrant glycosylation is a hallmark of cancer cells. The blood group precursors T (Thomsen-Friedenreich) and Tn epitopes are shielded in healthy and benign-diseased tissues but uncovered in approximately 90% of carcinomas. T and Tn glycoproteins are specific, autoimmunogenic pancarcinoma antigens. These antigens may also be found in neoplastic blood cells. Fundamental, chemical and physical aspects of these glycoproteins of primary carcinomas are discussed first. Tn and T epitopes are cell and tissue adhesion molecules, essential in invasion by and metastasis of carcinoma which includes adherent and proliferative phases. Immunohistochemical studies of the extent of Tn antigen expression in primamry breast carcinoma demonstrate its highly significant correlation with clinical pathological tumor stages, and hence its value as a reliable prognisticator.

Specifications

• Antigen: Tn Antigen
• Classification: Monoclonal
• Concentration: 0.20 mg/mL
• Formulation: PBS with 0.05% sodium azide; pH 7.2
• Host Species: Mouse
• Purification Method: Purified
• Regulatory Status: RUO
• Target Species: Human
• Product Type: Antibody
• Isotype: IgM

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: Tn 218
• Conjugate: Unconjugated
• Gene Alias: Thomsen-Friedenreich antigen
• Immunogen: Asialo ovine submaxillary mucin (AOSM).
• Quantity: 500 μL
• Primary or Secondary: Primary
• Content And Storage: 4°C, do not freeze
• Form: Liquid