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TNF alpha Antibody Cocktail, Invitrogen™

Catalog No. AHC3712
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AHC3712 500 μg
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Catalog No. AHC3712 Supplier Invitrogen Supplier No. AHC3712

Description

Antibody Cocktail

This monoclonal mixture is recommended as a capture antibody in Sandwich ELISA applications. This clone can also be referred to as clone number 68B 2B3 BC6/68B 6A3 1H8 1F2. Clone 68B2B3 isotype is undetermined. Clone 68B6A3 isotype is IgG1.

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TNF alpha
Applications ELISA
Classification Cocktail
Clone 68B2B3 and 68B6A3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.5mg/mL sodium azide; pH 7.4
Gene Tnf
Gene Accession No. P01375
Gene Alias APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
Gene Symbols Tnf
Host Species Mouse
Immunogen Purified recombinant human TNF-alpha.
Purification Method Protein A
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7124
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype Ig Mix
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