Invitrogen™ TNF beta Monoclonal Antibody (LTX-22), eBioscience™

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ BMS1046

Catalog No. 50-177-15

Description

Description: BMS1046 (LTX-22) is reportded for ELISA and ICH applications. Applications Tested: ELISA, Immunohistochemistry (Frozen). Source: Plant expressed 164 amino acids (Cys32-Thr194) with 16 amino acid Histidine tag. accession NP_002000. Bioactivity: The ED50 of this protein, as measured by proliferation assay of 4MBr5 monkey epthelial cells, is less than or equal to 4 ng/mL. This corresponds to a specific activity of greater than or equal to 2.5 x 10e5 Units/mg. Endotoxin: Less than 0.005 ng/ug (0.05 EU/ug) as measured by turbidity assay. Purity: Greater than or equal to 95% as determined by SDS-PAGE. Molecular Weight: 21.2 kDa but with glycosylation the apparent molecular weights are 26 and 28 kDa.

TNF beta, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4 and psoriatic arthritis.

Specifications

• Antigen: TNF beta
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7.2-7.4
• Gene Accession No.: P01374
• Gene Symbols: LTA
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4049
• Content And Storage: -20°C
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Frozen)
• Clone: LTX-22
• Conjugate: Unconjugated
• Gene: LTA
• Gene Alias: DAMA-25N12.13; hlb382; hypothetical protein; LT; LT[a]; LT-[a]; LTA; LTalpha; LT-alpha; Ltx; lymphotoxin A; lymphotoxin alpha; lymphotoxin alpha (TNF superfamily, member 1); lymphotoxin-alpha; lymphotoxin-alpha; lymphotoxin alpha; TNF b; TNF beta; TNF superfamily, member 1; TNF ß; Tnfb; TNFbeta; TNF-beta; TNF-N; Tnfsf1; Tnfsf1b; TNFß; TNLG1E; tumor necrosis factor beta; tumor necrosis factor ligand 1E; tumor necrosis factor ligand superfamily member 1
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1