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TNF Rat anti-Mouse, PE-Cy7, Clone: MP6-XT22, BD

Catalog No. BDB561041 Shop All BD Biosciences Products
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BDB561041 25 μg
BDB557644 0.1 mg
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Catalog No. BDB561041 Supplier BD Biosciences Supplier No. 561041
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Description

Rat Monoclonal Antibody

The MP6-XT22 antibody specifically binds to mouse Tumor Necrosis Factor (TNF, also known as TNF-α). TNF is produced by many activated cell types including monocytes, macrophages, astrocytes, granulocytes, mast cells, T and B lymphocytes, NK cells, keratinocytes, fibroblasts, adipocytes, and certain tumor cells. Activated cells express type II transmembrane TNF glycoproteins that associate as homotrimeric complexes. After enzymatic cleavage, the extracellular regions of membrane TNF are shed as soluble homotrimers. TNF is a potent multifunctional cytokine that can exert regulatory and cytotoxic effects on a wide range of normal lymphoid and non-lymphoid cells and tumor cells. Although TNF serves as a primary mediator in protective immune responses against microbial and viral pathogens, it can also drive systemic pathophysiologic responses including septic shock, cachexia and autoimmune diseases. Mouse TNF exerts its biological activities by binding and signaling through cell surface membrane Type I and Type II TNF Receptors (aka, TNFRI/CD120a and TNFRII/CD120b, respectively).

TRUSTED_SUSTAINABILITY

Specifications

Antigen TNF
Applications Flow Cytometry
Classification Monoclonal
Clone MP6-XT22
Concentration 0.2mg/mL
Conjugate PE-Cyanine7
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Recombinant Mouse TNF
Purification Method Affinity Purified
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1
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For Research Use Only.

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