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TNFA Mouse anti-Human, Clone: OTI3H10, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF808184

Catalog No. 50-166-8676


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Specifications

Specifications

TNFA
Monoclonal
Unconjugated
TNF
Lyophilized
TNF
Full length human recombit protein of human TNF produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Western Blot
OTI3H10
PBS with 8% trehalose and no preservative; pH 7.3
P01375
DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
7124
SDS
Documents
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