Invitrogen™ TNFAIP3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA585357

Catalog No. PIPA585357

Description

Keep as concentrated solution. Predicted reactivity: Mouse (83%), Pig (81%), Rhesus Monkey (97%). Positive Control: 3xFlag-human TNFAIP3-transfected 293T. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.

Specifications

• Antigen: TNFAIP3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TNFAIP3
• Gene Alias: A20; A20p37; A20p50; AISBL; OTU domain-containing protein 7C; OTUD7C; Putative DNA-binding protein A20; RP11-356I2.3; TNF alpha induced protein 3; TNF alpha-induced protein 3; TNFA1P2; TNFAIP3; TNFAIP3 (A20); Tnfip3; Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; tumor necrosis factor, alpha-induced protein 3; zinc finger protein A20
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7128
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.67 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: P21580
• Gene Symbols: TNFAIP3
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human TNFAIP3. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG