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Invitrogen™ TNFAIP3 Polyclonal Antibody
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Catalog No. PIPA596064
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100 μL
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PIPA596064 100 μL
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Catalog No. PIPA596064 Supplier Invitrogen™ Supplier No. PA596064
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DRTGTSKCRK AGCVYFGTPE NKGFCTLCFI EYRENKHFAA ASGKVSPTAS RFQNTIPCLG RECGTLGSTM FEGYCQKCFI EAQNQRFHEA KRTEEQLRSS QRRDVPRTTQ STSRPKCARA SCKNILACRS EELCMECQH Positive Samples: Jurkat, HepG2, SW480, Mouse spleen; Cellular Location: Cytoplasm, Lysosome, Nucleus.

TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TNFAIP3
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.59 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene TNFAIP3
Gene Accession No. P21580, Q60769
Gene Alias A20; A20p37; A20p50; AISBL; OTU domain-containing protein 7C; OTUD7C; Putative DNA-binding protein A20; RP11-356I2.3; TNF alpha induced protein 3; TNF alpha-induced protein 3; TNFA1P2; TNFAIP3; TNFAIP3 (A20); Tnfip3; Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; tumor necrosis factor, alpha-induced protein 3; zinc finger protein A20
Gene Symbols TNFAIP3
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 600-738 of human TNFAIP3 (NP_0062811).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21929, 683206, 7128
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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