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TNFAIP3 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501984979
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50-198-4979 100 μL
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Catalog No. 50-198-4979 Supplier Bioss Supplier No. BS2803R
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Description

Rabbit Polyclonal Antibody

TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.

Specifications

Antigen TNFAIP3
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene TNFAIP3
Gene Accession No. P21580
Gene Alias A20; A20p37; A20p50; AISBL; OTU domain-containing protein 7C; OTUD7C; Putative DNA-binding protein A20; RP11-356I2.3; TNF alpha induced protein 3; TNF alpha-induced protein 3; TNFA1P2; Tnfaip3; TNFAIP3 (A20); Tnfip3; Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; tumor necrosis factor, alpha-induced protein 3; Zinc finger protein A20
Gene Symbols TNFAIP3
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human TNFAIP3.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7128
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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