Invitrogen™ TNFAIP3 Recombinant Rabbit Monoclonal Antibody (0K8B0)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA535277

Catalog No. PIMA535277

Description

Immunogen sequence: PEESTGGPHS APPTAPSPFL FSETTAMKCR SPGCPFTLNV QHNGFCERCH NARQLHASHA PDHTRHLDPG KCQACLQDVT RTFNGICSTC FKRTTAEASS S.

TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.

Specifications

• Antigen: TNFAIP3
• Classification: Recombinant Monoclonal
• Concentration: 0.95 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P21580
• Gene Symbols: TNFAIP3
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 450-550 of human TNFAIP3 (P21580).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 0K8B0
• Conjugate: Unconjugated
• Gene: TNFAIP3
• Gene Alias: A20; A20p37; A20p50; AISBL; OTU domain-containing protein 7C; OTUD7C; Putative DNA-binding protein A20; RP11-356I2.3; TNF alpha induced protein 3; TNF alpha-induced protein 3; TNFA1P2; TNFAIP3; TNFAIP3 (A20); Tnfip3; Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; tumor necrosis factor, alpha-induced protein 3; zinc finger protein A20
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7128
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid