DescriptionTNFalpha-IP 8 (tumor necrosis factor, alpha-induced protein 8), also known as NFkappa B-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFkappa B and TNF. The induction of TNFalpha-IP 8 by TNF is dependent on the activation of NFkappa B. TNFalpha-IP 8 negatively mediates apoptosis and may also play a role in tumor progression. TNFalpha-IP 8 specifically inhibits caspase-8 activity, which results in the inhibition of BID cleavage and caspase-3 activation during TNF-mediated apoptosis. TNFalpha-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta and various tumor tissues, as well as fetal lung, liver and kidney. TNFalpha-IP 8 is present as three isoforms produced by alternative splicing.
|Immunohistochemistry (Paraffin), Western Blot|
|Human, Mouse, Rat|
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|Antigen Affinity Chromatography|
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