Invitrogen™ TNFAIP8 Recombinant Rabbit Monoclonal Antibody (24GB2315)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA557784

Catalog No. MA557784

Description

TNFAIP8 Recombinant Monoclonal Antibody for Western Blot, Flow

TNFalpha-IP 8 (tumor necrosis factor, alpha-induced protein 8), also known as NFkappa B-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFkappa B and TNF. The induction of TNFalpha-IP 8 by TNF is dependent on the activation of NFkappa B. TNFalpha-IP 8 negatively mediates apoptosis and may also play a role in tumor progression. TNFalpha-IP 8 specifically inhibits caspase-8 activity, which results in the inhibition of BID cleavage and caspase-3 activation during TNF-mediated apoptosis. TNFalpha-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta and various tumor tissues, as well as fetal lung, liver and kidney. TNFalpha-IP 8 is present as three isoforms produced by alternative splicing.

Specifications

• Antigen: TNFAIP8
• Classification: Recombinant Monoclonal
• Conjugate: Unconjugated
• Gene: Tnfaip8
• Gene Alias: AA987150; E130304C20Rik; ENSMUSG00000073567; GG2-1; Gm10539; head and neck tumor and metastasis-related protein; MDC3.13; MDC-3.13; Nded; NF-kappa-B-inducible DED-containing protein; SCC S2; SCCS2; SCC-S2; Ssc-2; TNF alpha induced protein 8; TNF alpha-induced protein 8; Tnfaip8; TNFalpha IP8; TNFalpha-IP 8; TNFalphaIP8; TNF-induced protein; TNF-induced protein GG2-1; Tumor necrosis factor alpha-induced protein 8; tumor necrosis factor, alpha induced protein 8; tumor necrosis factor, alpha-induced protein 8
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 106869, 25816, 307428
• Content And Storage: -20°C
• Form: Liquid

• Applications: Flow Cytometry, Western Blot
• Clone: 24GB2315
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O95379, Q921Z5
• Gene Symbols: Tnfaip8
• Immunogen: A synthesized peptide derived from human TNFAIP8 (aa 1-35).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG