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TNFAIP8 Mouse anti-Human, Clone: OTI1H9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527345

Catalog No. PIMA527345


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Description

Description

TNFalpha-IP 8 (tumor necrosis factor, alpha-induced protein 8), also known as NFκB-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFκB and TNF. The induction of TNFalpha-IP 8 by TNF is dependent on the activation of NFκB. TNFalpha-IP 8 negatively mediates apoptosis and may also play a role in tumor progression. TNFalpha-IP 8 specifically inhibits caspase-8 activity, which results in the inhibition of BID cleavage and caspase-3 activation during TNF-mediated apoptosis. TNFalpha-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta and various tumor tissues, as well as fetal lung, liver and kidney. TNFalpha-IP 8 is present as three isoforms produced by alternative splicing.
Specifications

Specifications

TNFAIP8
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O95379
Tumor necrosis factor alpha-induced protein 8; TNF alpha-induced protein 8; Head and neck tumor and metastasis-related protein; MDC-3.13; MDC3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; SCC S2; SCCS2; TNF-induced protein GG2-1; TNFAIP8; TNFalpha IP8; TNFalphaIP8; TNFalpha-IP 8
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
25816
Immunohistochemistry (Paraffin), Western Blot
OTI1H9
Unconjugated
TNFAIP8
Liquid
TNFAIP8
Full length human recombit protein of TNFAIP8 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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