TNFAIP8 Mouse anti-Human, Clone: OTI1H9, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527345
DescriptionTNFalpha-IP 8 (tumor necrosis factor, alpha-induced protein 8), also known as NFκB-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFκB and TNF. The induction of TNFalpha-IP 8 by TNF is dependent on the activation of NFκB. TNFalpha-IP 8 negatively mediates apoptosis and may also play a role in tumor progression. TNFalpha-IP 8 specifically inhibits caspase-8 activity, which results in the inhibition of BID cleavage and caspase-3 activation during TNF-mediated apoptosis. TNFalpha-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta and various tumor tissues, as well as fetal lung, liver and kidney. TNFalpha-IP 8 is present as three isoforms produced by alternative splicing.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Tumor necrosis factor alpha-induced protein 8; TNF alpha-induced protein 8; Head and neck tumor and metastasis-related protein; MDC-3.13; MDC3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; SCC S2; SCCS2; TNF-induced protein GG2-1; TNFAIP8; TNFalpha IP8; TNFalphaIP8; TNFalpha-IP 8|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of TNFAIP8 produced in HEK293T cell|
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