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TNFRSF10B Mouse anti-Human, Clone: OTI4B12, lyophilized, TrueMAB™
SDP

Catalog No. 501668197
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100 μg
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50-166-8197 100 μg
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Catalog No. 50-166-8197 Supplier OriGene Supplier No. CF807291
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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome.

Specifications

Antigen TNFRSF10B
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI4B12
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene TNFRSF10B
Gene Accession No. O14763
Gene Alias CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
Gene Symbols TNFRSF10B
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 203-411 of human TNFRSF10B produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8795
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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