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TNFRSF10B Mouse anti-Human, Mouse, Clone: OTI2A5, liquid, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene TA807323

Description
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome.Specifications
TNFRSF10B | |
Monoclonal | |
1 mg/mL | |
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
O14763, Q9QZM4 | |
Tnfrsf10b | |
Human recombit protein fragment corresponding to amino acids 203-411 of human TNFRSF10B produced in E.coli. | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG1 |
Immunohistochemistry (Paraffin), Western Blot | |
OTI2A5 | |
Unconjugated | |
TNFRSF10B | |
CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 | |
Mouse | |
Affinity Chromatography | |
RUO | |
21933, 8795 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
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