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TNFRSF10B Mouse anti-Human, Mouse, Clone: OTI2A5, liquid, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA807323

Encompass_Preferred

Catalog No. 50-168-1494


May include imposed supplier surcharges.
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Description

Description

DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome.
Specifications

Specifications

TNFRSF10B
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
O14763, Q9QZM4
Tnfrsf10b
Human recombit protein fragment corresponding to amino acids 203-411 of human TNFRSF10B produced in E.coli.
100 μL
Primary
Human, Mouse
Antibody
IgG1
Immunohistochemistry (Paraffin), Western Blot
OTI2A5
Unconjugated
TNFRSF10B
CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
Mouse
Affinity Chromatography
RUO
21933, 8795
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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