Invitrogen™ TNFRSF14 (HVEM) Recombinant Rabbit Monoclonal Antibody (BLR062G)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA544317

Catalog No. PIMA544317

Description

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

TNFRSF14 is a member of the TNF-receptor superfamily. TNFRSF14 was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to TNFRSF14 has been shown to be part of the viral entry mechanism. The cytoplasmic region of TNFRSF14 was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. Activation of the signal transduction pathway involving TNFRSF14 in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these TNFRSF14 variants have not been determined.

Specifications

• Antigen: TNFRSF14 (HVEM)
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: BBS with 0.09% sodium azide; pH 8.2
• Gene Accession No.: Q92956
• Gene Symbols: TNFRSF14
• Immunogen: Recombinant protein representing the extracellular domain of human TNF receptor superfamily member 14, transcript variant 1 (Herpesvirus entry mediator A, HVEM) (residues 39-200).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: BLR062G
• Conjugate: Unconjugated
• Gene: TNFRSF14
• Gene Alias: Atar; CD270; CD40-like protein; herpes virus entry mediator; herpes virus entry mediator A; Herpesvirus entry mediator A; HGNC:11912; HVEA; Hvem; LIGHTR; RP3-395M20.6; sCD2710; TNF receptor superfamily member 14; Tnfrs14; TNFRSF14; TR2; tumo; Tumor necrosis factor receptor superfamily member 14; tumor necrosis factor receptor superfamily, member 14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); Tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2; UNQ329/PRO509
• Host Species: Rabbit
• Purification Method: purified
• Regulatory Status: RUO
• Gene ID (Entrez): 8764
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

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