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TNFRSF14 Monoclonal Antibody (122), Invitrogen™

Catalog No. PIMA513986
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500 μL
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Catalog No. Quantity
PIMA513986 500 μL
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Catalog No. PIMA513986 Supplier Thermo Scientific Supplier No. MA513986
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Description

Mouse Monoclonal Antibody

MA5-13986 targets TR2/HVEM in FACS, and IF applications and shows reactivity with Human samples. The MA5-13986 immunogen is recombinant human TR2 protein.

TNFRSF14 is a member of the TNF-receptor superfamily. TNFRSF14 was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to TNFRSF14 has been shown to be part of the viral entry mechanism. The cytoplasmic region of TNFRSF14 was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. Activation of the signal transduction pathway involving TNFRSF14 in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these TNFRSF14 variants have not been determined.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TNFRSF14
Applications Flow Cytometry, Immunocytochemistry
Classification Monoclonal
Clone 122
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene TNFRSF14
Gene Accession No. Q92956
Gene Alias Atar; CD270; CD40-like protein; herpes virus entry mediator; herpes virus entry mediator A; Herpesvirus entry mediator A; HGNC:11912; HVEA; Hvem; LIGHTR; RP3-395M20.6; sCD2710; TNF receptor superfamily member 14; Tnfrs14; TNFRSF14; TR2; tumo; Tumor necrosis factor receptor superfamily member 14; tumor necrosis factor receptor superfamily, member 14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); Tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2; UNQ329/PRO509
Gene Symbols TNFRSF14
Host Species Mouse
Immunogen Recombinant human TR2 protein
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8764
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1
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