TNFRSF14 Monoclonal Antibody (OTI1F12), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA808083

Catalog No. 50-168-1905

Description

TNFRSF14 is a member of the TNF-receptor superfamily. TNFRSF14 was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to TNFRSF14 has been shown to be part of the viral entry mechanism. The cytoplasmic region of TNFRSF14 was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. Activation of the signal transduction pathway involving TNFRSF14 in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these TNFRSF14 variants have not been determined.

Specifications

• Antigen: TNFRSF14
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q92956
• Gene Symbols: TNFRSF14
• Immunogen: Human recombit protein fragment corresponding to amino acids 39-283 of human TNFRSF14 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI1F12
• Conjugate: Unconjugated
• Gene: TNFRSF14
• Gene Alias: ATAR, CD270, HVEA, HVEM, LIGHTR, TR2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8764
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid