TNFRSF14 Mouse anti-Human, Clone: OTI1A7, lyophilized, TrueMAB™

Catalog No.	Quantity
50-166-8630	100 μg

Catalog No. 50-166-8630 Supplier OriGene Supplier No. CF808093

Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

TNFRSF14 is a member of the TNF-receptor superfamily. TNFRSF14 was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to TNFRSF14 has been shown to be part of the viral entry mechanism. The cytoplasmic region of TNFRSF14 was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. Activation of the signal transduction pathway involving TNFRSF14 in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these TNFRSF14 variants have not been determined.

Specifications

• Antigen: TNFRSF14
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI1A7
• Conjugate: Unconjugated
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene: TNFRSF14
• Gene Accession No.: Q92956
• Gene Alias: ATAR, CD270, HVEA, HVEM, LIGHTR, TR2
• Gene Symbols: TNFRSF14
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 39-283 of human TNFRSF14 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8764
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1