TNFRSF4 Mouse anti-Human, Clone: UMAB276, liquid, UltraMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene UM870166

Catalog No. 50-168-5612

Description

OX40 (CD134) is a member of the TNF-receptor superfamily, and has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that OX40 promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.OX40 is not constitutively expressed on resting naive T cells, unlike CD28. OX40 is a secondary costimulatory molecule, expressed after 24 to 72 hours following activation. OX40L, a ligand of OX40, is also not expressed on resting antigen presenting cells. Expression of OX40 is dependent on full activation of the T cell; without CD28, expression of OX40 is delayed and expressed at lower levels.

Specifications

• Antigen: TNFRSF4
• Classification: Monoclonal
• Concentration: 0.5-1.0 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P43489
• Gene Symbols: TNFRSF4
• Immunogen: Full length human recombit protein of human TNFRSF4 produced in HEK293T cell.
• Quantity: 30 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin)
• Clone: UMAB276
• Conjugate: Unconjugated
• Gene: TNFRSF4
• Gene Alias: ACT35, CD134, IMD16, OX40, TXGP1L
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7293
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid