Invitrogen™ TNIK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA533085

Catalog No. PIPA533085

Description

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Bat, Rabbit (100%); Dog, Elephant, Panda, Horse (94%); Mouse, Rat (89%); Bovine (83%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

TNIK or TRAF2 and NCK interacting kinase is characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function. TNIK is mainly expression in brain, heart, and spleen and it is a specific effector of RAP2 which regulate actin cytoskeleton. TNIK is autophosphorylated in a manner dependent upon lys54 in the ATP-binding pocket of its kinase domain and plays a main role in cytoskeleton regulation. TNIK has also been shown to phosphorylate gelsolin, the principal intracellular and extracellular actin-severing protein, in vitro. This and evidence from mutational studies suggest that TNIK functions in the regulation of the cytoskeleton.

Specifications

• Antigen: TNIK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TNIK
• Gene Alias: 1500031A17Rik; 4831440I19Rik; AI451411; C530008O15Rik; C630040K21Rik; KIAA0551; RGD1561817; Tnik; TRAF2 and NCK interacting kinase; TRAF2 and NCK-interacting protein kinase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100339162, 23043
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: Q9UKE5
• Gene Symbols: TNIK
• Immunogen: Synthetic 18 amino acid peptide from internal region of human TNIK.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Rabbit, Monkey, Bat
• Product Type: Antibody
• Isotype: IgG