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Invitrogen™ TNIK Polyclonal Antibody
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Catalog No. PIPA5116058
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100 μL
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PIPA5116058 100 μL
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Catalog No. PIPA5116058 Supplier Invitrogen™ Supplier No. PA5116058
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total TNIK.

TNIK or TRAF2 and NCK interacting kinase is characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function. TNIK is mainly expression in brain, heart, and spleen and it is a specific effector of RAP2 which regulate actin cytoskeleton. TNIK is autophosphorylated in a manner dependent upon lys54 in the ATP-binding pocket of its kinase domain and plays a main role in cytoskeleton regulation. TNIK has also been shown to phosphorylate gelsolin, the principal intracellular and extracellular actin-severing protein, in vitro. This and evidence from mutational studies suggest that TNIK functions in the regulation of the cytoskeleton.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TNIK
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene TNIK
Gene Accession No. P83510, Q9UKE5
Gene Alias 1500031A17Rik; 4831440I19Rik; AI451411; C530008O15Rik; C630040K21Rik; KIAA0551; RGD1561817; Tnik; TRAF2 and NCK interacting kinase; TRAF2 and NCK-interacting protein kinase
Gene Symbols TNIK
Host Species Rabbit
Immunogen A synthesized peptide derived from human TNIK(Accession Q9UKE5), corresponding to amino acid residues R663-R713.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23043, 665113
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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