Invitrogen™ TNIK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA120639

Catalog No. PIPA120639

Description

Suggested positive controls for this product are heart, skeletal muscle and brain. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

TNIK or TRAF2 and NCK interacting kinase is characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function. TNIK is mainly expression in brain, heart, and spleen and it is a specific effector of RAP2 which regulate actin cytoskeleton. TNIK is autophosphorylated in a manner dependent upon lys54 in the ATP-binding pocket of its kinase domain and plays a main role in cytoskeleton regulation. TNIK has also been shown to phosphorylate gelsolin, the principal intracellular and extracellular actin-severing protein, in vitro. This and evidence from mutational studies suggest that TNIK functions in the regulation of the cytoskeleton.

Specifications

• Antigen: TNIK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TNIK
• Gene Alias: 1500031A17Rik; 4831440I19Rik; AI451411; C530008O15Rik; C630040K21Rik; KIAA0551; RGD1561817; Tnik; TRAF2 and NCK interacting kinase; TRAF2 and NCK-interacting protein kinase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23043, 665113
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.01% sodium azide
• Gene Accession No.: P83510, Q9UKE5
• Gene Symbols: TNIK
• Immunogen: Synthetic peptide with a proprietary sequence.
• Quantity: 25 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov