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Invitrogen™ TNIP2 Polyclonal Antibody
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Catalog No. 01675745
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100 μg
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Catalog No. Quantity
01-675-745 100 μg
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Catalog No. 01-675-745 Supplier Invitrogen™ Supplier No. PA141174
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Description

Rabbit Polyclonal Antibody

Suggested positive control: antigen standard for TNIP2 (transient overexpression lysate), mouse heart or lung tissue, mouse heart protein.

TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TNIP2
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.05% sodium azide
Gene Tnip2
Gene Accession No. Q8NFZ5, Q99JG7
Gene Alias 1810020H16Rik; A20 binding inhibitor of NF-kappaB activation-2; A20-binding inhibitor of NF-kappa-B activation 2; A20-binding inhibitor of NF-kappaB activation-2; ABIN2; ABIN-2; AI428870; Fetal liver LKB1-interacting protein; FLIP1; KLIP; TNFAIP3 interacting protein 2; TNFAIP3-interacting protein 2; Tnip2
Gene Symbols Tnip2
Host Species Rabbit
Immunogen Synthetic peptides of human ABIN-2.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 231130, 305451, 79155
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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