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Invitrogen™ TNIP2 Polyclonal Antibody
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Catalog No. PIPA564096
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100 μL
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PIPA564096 100 μL
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Catalog No. PIPA564096 Supplier Invitrogen™ Supplier No. PA564096
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: EDLNAKWQRY NASRDEYVRG LHAQLRGLQI PHEPELMRKE ISRLNRQLEE KINDCAEVKQ ELAASRTARD AALERVQM Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 82%.

TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TNIP2
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Tnip2
Gene Accession No. Q8NFZ5
Gene Alias 1810020H16Rik; A20 binding inhibitor of NF-kappaB activation-2; A20-binding inhibitor of NF-kappa-B activation 2; A20-binding inhibitor of NF-kappaB activation-2; ABIN2; ABIN-2; AI428870; Fetal liver LKB1-interacting protein; FLIP1; KLIP; TNFAIP3 interacting protein 2; TNFAIP3-interacting protein 2; Tnip2
Gene Symbols Tnip2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TNIP2. Recombinant protein control fragment (Product #RP-104131).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79155
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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