TNIP2 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-7834	100 μL

Catalog No. 50-198-7834 Supplier Bioss Supplier No. BS7563R

Description

Rabbit Polyclonal Antibody

TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.

Specifications

• Antigen: TNIP2
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: Tnip2
• Gene Accession No.: Q8NFZ5
• Gene Alias: 1810020H16Rik; A20 binding inhibitor of NF-kappaB activation-2; A20-binding inhibitor of NF-kappa-B activation 2; A20-binding inhibitor of NF-kappaB activation-2; Abin2; ABIN-2; AI428870; Fetal liver LKB1-interacting protein; FLIP1; KLIP; TNFAIP3 interacting protein 2; TNFAIP3-interacting protein 2; Tnip2
• Gene Symbols: Tnip2
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human TNIP2/ABIN2.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 79155
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG