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Invitrogen™ TNNI2 Monoclonal Antibody (2F12A8)
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Catalog No. PIMA515913
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100 μL
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PIMA515913 100 μL
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Catalog No. PIMA515913 Supplier Invitrogen™ Supplier No. MA515913
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Description

Mouse Monoclonal Antibody

MA5-15913 targets TNNI2 in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with Human samples. The MA5-15913 immunogen is purified recombinant fragment of human TNNI2 expressed in E. Coli. . MA5-15913 detects TNNI2 which has a predicted molecular weight of approximately 21kDa.

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TNNI2
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 2F12A8
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation ascites with 0.03% sodium azide
Gene Tnni2
Gene Accession No. P13412, P48788
Gene Alias AMCD2B; DA2B; FSSV; fsTnI; TnI; TNNI2; troponin 1, type 2; troponin I; troponin I fast twitch 2; troponin I type 2 (skeletal, fast); troponin I, fast skeletal muscle; Troponin I, fast-twitch isoform; troponin I, fast-twitch skeletal muscle isoform; troponin I, skeletal, fast; troponin I, skeletal, fast 2; troponin I2, fast skeletal type; Trp1
Gene Symbols Tnni2
Host Species Mouse
Immunogen Purified recombinant fragment of human TNNI2 expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21953, 7136
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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