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Invitrogen™ TNNI2 Polyclonal Antibody
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Catalog No. PIPA596869
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100 μL
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PIPA596869 100 μL
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Catalog No. PIPA596869 Supplier Invitrogen™ Supplier No. PA596869
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEESRREAE KQNYLAEHCP PLHIPGSMSE VQELCKQLHA KIDAAEEEKY DMEVRVQKTS KELEDMNQKL; Positive Samples: Mouse skeletal muscle, Rat skeletal muscle.

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TNNI2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 2.48 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Tnni2
Gene Accession No. P13412, P27768
Gene Alias AMCD2B; DA2B; FSSV; fsTnI; TnI; TNNI2; troponin 1, type 2; troponin I; troponin I fast twitch 2; troponin I type 2 (skeletal, fast); troponin I, fast skeletal muscle; Troponin I, fast-twitch isoform; troponin I, fast-twitch skeletal muscle isoform; troponin I, skeletal, fast; troponin I, skeletal, fast 2; troponin I2, fast skeletal type; Trp1
Gene Symbols Tnni2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human Troponin I2 (Troponin I2 (TNNI2)) (NP_0032731).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21953, 29389
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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