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TNNI3 Monoclonal Antibody (OTI13E9), TrueMAB™, OriGene
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA807856

Encompass_Preferred

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Catalog No. 50-168-1806


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Description

Description

Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
Specifications

Specifications

TNNI3
Monoclonal
Unconjugated
TNNI3
CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI
Mouse
Affinity Chromatography
RUO
7137
-20° C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot
OTI13E9
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P19429
TNNI3
Full length human recombit protein of human TNNI3 produced in HEK293T cell.
100 μL
Primary
Human
Antibody
IgG2a
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