Invitrogen™ TNNT1 Polyclonal Antibody

Catalog No.	Quantity
PIPA587835	100 μL

Catalog No. PIPA587835 Supplier Invitrogen™ Supplier No. PA587835

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MSDTEEQEYE EEQPEEEAAE EEEEAPEEPE PVAEPEEERP KPSRPVVPPL IPPKIPEGER VDFDDIHRKR MEKDLLELQT LIDVHFEQRK KEEEELVALK ERIERRRSER AEQQRFRTEK ERERQAKLAE EKMRKEEEEA KKRAEDDAKK KKVLSNMGAH FGGYLVKAEQ KRGKRQTGRE MKVRILSERK KPLDIDYMGE EQLREKAQEL SDWIHQLESE KFDLMAKLKQ QKYEINVLYN RISHAQKFRK GAGKGRVGGR WK; Positive Samples: HT-1080, A-549, SW480.

This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: TNNT1
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 1.62 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: TNNT1
• Gene Accession No.: P13805
• Gene Alias: ANM; AW146156; Fang2; MGC104241; NEM5; skeletal muscle slow-twitch TnT; slow skeletal muscle troponin T; ssTnT; sTnT; Tnnt1; TNT; TNTS; troponin T slow skeletal muscle type; troponin T slow type isoform sTnT1; troponin T slow type isoform sTnT2; troponin T type 1 (skeletal, slow); troponin T, slow skeletal muscle; troponin T1, skeletal, slow; troponin T1, slow skeletal type; troponin-T1, skeletal, slow; zgc:193831; zgc:193865
• Gene Symbols: TNNT1
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-262 of human TNNT1 (NP_0011196041).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7138
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG